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导师风采


药学院副院长 国家万人计划 国家药典委员会委员 国家科技进步一等奖

个人简介

   陆晓燕 副教授

博士生导师

药学院307Luxy@zju.edu.cn0571-88208426

38岁主页:http://person.zju.edu.cn/luxy


陆晓燕,博士、副教授陆晓燕,博士、副教授  浙江大学学士(2004年)、中国科学院生物物理研究所分子生物学博士(2009年)、美国哈佛大学公共卫生学院博士后(2014-2015年)。现任浙江大学药学院副教授。主要从事药物及纳米材料安全性研究,为主完成了多个中药及纳米材料的毒理基因组学评价。主持国家自然科学基金“基于循环exosomes的川楝子肝毒性生物标志物发现及毒性机制研究”(No.81403275),国家科技重大专项子课题“注射用血塞通安全性、质量控制及再评价研究”(No. 2014ZX09201022-009)等安全性相关项目10余项,以第一或通讯作者(含共同)在Journal of Controlled Release、Nanotoxicology、Food Chem Toxicol 等期刊发表SCI 近30篇。担任中华中医药学会中药毒理学与安全性研究分会委员、中国中西医结合学会首届临床药理与毒理专业委员会青年委员。


研究成果

主持国家自然科学基金“基于循环exosomes的川楝子肝毒性生物标志物发现及毒性机制研究”(No.81403275),国家科技重大专项子课题“注射用血塞通安全性、质量控制及再评价研究”(No. 2014ZX09201022-009)等安全性相关项目10余项,以第一或通讯作者(含共同)在Journal of Controlled Release、Nanotoxicology、Food Chem Toxicol等期刊发表SCI 近30篇。


研究项目

1.基于循环exosomes的川楝子肝毒性生物标志物发现及毒性机制研究(81403275), 纵向, 国家自然科学青年基金, 23万元, 2015-01至2017-12, 陆晓燕(负责人)

2.基于表观遗传学的食品级二氧化硅潜在肝毒性研究(LY17B070003), 纵向, 浙江省自然科学基金, 8万元, 2017-01至2019-12, 陆晓燕(负责人)

3.参麦注射液标准化建设(ZYBZH-C-ZJ-60), 纵向, 国家中药标准化项目子课题任务, 100万元, 2016-01至2018-12,陆晓燕(负责人)

4.毒性生物标志物与人源化动物模型关键技术研究(2012ZX09505001-001), 纵向, 国家科技重大专项子课题任务, 80万元, 2012-01至2015-12, 陆晓燕(负责人)

5.注射用血塞通安全性、质量控制及再评价研究(2014ZX09201022-009), 纵向, 国家科技重大专项子课题任务, 80万元, 2014-01至2016-12, 陆晓燕(负责人)

6.现代中药创新集群与数字制药技术平台(2013ZX09402203), 纵向, 国家科技重大专项子课题任务, 95万元, 2015-07至2016-11, 陆晓燕(负责人)

7.基于代谢组学的二氧化硅颗粒表面修饰与尺寸效应相关的肝脏毒性研究(LY13B070002), 纵向, 浙江省自然科学基金, 8万元, 2013-01至2015-12, 陆晓燕(负责人)

8.基于miRNAs的跨种属策略中药肝毒性原代肝细胞筛选与评价新方法(20120101120137), 纵向, 教育部博士点专项基金, 4万元, 2013-01至2015-12, 陆晓燕(负责人)


获奖荣誉

“药物的新型纳米输送系统研究” 2008年度获中国药学会科学技术类二等奖排名5/9;

获得2015年药学院青年教师教学比赛二等奖和浙江大学青年教师教学比赛优胜奖;获2017年药学院“石华玉青年教师奖教金”。


发表论文

1) Xiaoyan Lu, Isabelle R. Miousse, Sandra V. Pirela, Stepan Melnyk, Igor Koturbash*, Philip Demokritou*, Short-term exposure to engineered nanomaterials affects cellular epigenome, Nanotoxicology, 2016.02, VOL.10, NO.2, P140-150.

2) Xiaoyan Lu, Isabelle R. Miousse, Sandra V. Pirela, Jodene K. Moore, Stepan Melnyk, Igor Koturbash*, Philip Demokritou*, In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles, Nanotoxicology, 2016.05, VOL.10, NO.5, P629-639.

3) Xiaoyan Lu, Cai Ji, Tingting Jin, Xiaohui Fan*, The effects of size and surface modification of amorphous silica particles on biodistribution and liver metabolism in mice, Nanotechnology (TOP期刊), 2015.05, VOL.26, NO.17, P175101. 
4) Xiaoyan Lu, Tingting Jin, Yachao Jin, Leihong Wu, Bin Hu, Yu Tian, Xiaohui Fan*, Toxicogenomic analysis of the particle dose- and size-response relationship of silica particles-induced toxicity in mice, Nanotechnology (TOP期刊), 2013.01, VOL.24, NO.1, P015106. 
5) Xiaoyan Lu, Yu Tian, Qinqin Zhao, Tingting Jin, Shun Xiao, Xiaohui Fan*, Integrated metabonomics analysis of the size-response relationship of silica nanoparticles-induced toxicity in mice, Nanotechnology (TOP期刊), 2011.02, VOL.22, NO.5, P055101. 
6) Lei Qin, Fayun Zhang, Xiaoyan Lu (并列第一作者), Xiuli Wei, Jing Wang, Xiaocui Fang, Duanyun Si, Yiguang Wang, Chunling Zhang, Rong Yang, Changxiao Liu*, Wei Liang*, Polymeric micelles for enhanced lymphatic drug delivery to treat metastatic tumors, Journal of Controlled Release (TOP期刊), 2013.10, VOL.171, NO.2, P133-142.

7) Jie Zheng, Yingqi Yu, Wen Chen, Xiaoyan Lu*, Xiaohui Fan*, Circulating exosomal microRNAs reveal the mechanism of Fructus Meliae Toosendan-induced liver injury in mice, Sci Rep. 2018 Feb 12;8(1):2832.

8) Xiaoyan Lu, Wei Tong, Shufang Wang, Jinghui Li, Jie Zheng, Xiaohui Fan*, Li Liu*, Comparison of the chemical consituents and immunomodulatory activity of ophiopogonis radix from two different producing areas, J Pharm Biomed Anal. 2017 Feb 5;134:60-70.

9) Xiaoyan Lu, Li Chen (并列第一作者), Ting Liu, Han Ke, Xingchu Gong, Qingqing Wang, Jianbing Zhang, Xiaohui Fan*, Chemical analysis, pharmacological activity and process optimization of the proportion of bilobalide and ginkgolides in Ginkgo biloba extract, J Pharm Biomed Anal. 2018 Oct 25;160: 46-54.
10) Xiaoyan Lu, Xueping Lian, Jie zheng, Ni Ai, Cai Ji, Cui Hao, Xiaohui Fan*, LC–ESI-TOF-MS-based metabolomic analysis of ginsenoside Rd-induced anaphylactoid reaction in mice, RSC Advances, 2016, VOL.6, NO.23, P19545-19554. 
11) Xiaoyan Lu, Bin Hu, Jie Zheng, Cai Ji, Xiaohui Fan*, Yue Gao*, Predose and Postdose Blood Gene Expression Profiles Identify the Individuals Susceptible to Acetaminophen-Induced Liver Injury in Rats, PLoS One, 2015.10, VOL.10, NO.10, Pe0141750. 
12) Xiaoyan Lu, Yu Tian, Xueping Lian, Yachao Jin, Tingting Jin, Qinqin Zhao, Bin Hu, Xiuping Shen, Xiaohui Fan*, Integrated systems toxicology approaches identified the possible involvement of ABC transporters pathway in erythromycin estolate-induced liver injury in rat, Food and Chemical Toxicology, 2014.03, VOL.65, P343-355. 
13) Xiaoyan Lu, Bin Hu, Li Shao, Yu Tian, Tingting Jin, Yachao Jin, Shen Ji*, Xiaohui Fan*, Integrated analysis of transcriptomics and metabonomics profiles in aflatoxin B1-induced hepatotoxicity in rat, Food and Chemical Toxicology, 2013.05, VOL.55, NO., P444-455.

14) Xiaoyan Lu, Qinqin Zhao, Yu Tian, Shun Xiao, Tingting Jin, Xiaohui Fan*, A metabonomics characterization of (+)-usnic acid-induced liver injury by gas chromatography-mass spectrometry-based metabolic profiling of the plasma and liver in rat, International Journal of Toxicology, 2011.10, VOL.30, NO.5, P478-491.

15) Xiaoyan Lu, Cai Ji, Wei Tong, Xueping Lian, Ying Wu, Xiaohui Fan*, Yue Gao*, Integrated analysis of microRNA and mRNA expression profiles highlights the complex and dynamic behavior of toosendanin induced liver injury in mice, Scientific Reports, 2016.10, VOL. 6, P34225.