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导师风采


药学院副院长 国家万人计划 国家药典委员会委员 国家科技进步一等奖

个人简介

   陈盛双 博士后

药学院332chenshsh@zju.edu.cn

32岁


陈盛双,博士,浙江大学药物信息学研究所博士后,博士毕业于澳门科技大学中药质量研究国家重点实验室,主要从事基于LC、SPE、MS、NMR和特征分子网络高效发掘活性分子,以及单细胞的质谱成像和代谢组学的研究。在Gut Microbes、Food Chemistry、Medicinal Research Reviews、Chemical Research in Toxicology、 Journal of Agricultural and Food Chemistry等期刊发表SCI论文12篇,获沈阳市自然科学学术成果三等奖1项,澳门科技研发奖1项。


学习经历

2018.09 —— 2022.04   澳门科技大学          博士(推荐)     中药学专业

2015.09 —— 2018.06   沈阳药科大学          硕士(推免)     天然药物化学专业

2011.09 —— 2015.06   长春中医药大学       学士                   药学(临床药学)专业


获奖情况

2014年,"创青春" 全国大学生创业大赛                                 国家级铜奖

2015年,第五届辽宁省创新创业(生物医药类)大赛              三等奖

2016年“中普杯”辽宁省大学生创新创业大赛                     一等奖

2017年,获沈阳市自然科学学术成果三等奖

2022年,获澳门研究生科技研发奖


发表论文

1. Gong, S.; Hu, X.; Chen, S.-S.; Sun, B.; Wu, J.-L.; Li, N., Dual roles of drug or its metabolite−protein conjugate: Cutting-edge strategy of drug discovery using shotgun proteomics. Medicinal Research Reviews 2022, 42 (4), 1704-1734.

2. Wang, X.; Li, N.; Chen, S.-S.; Ge, Y.-H.; Xiao, Y.; Zhao, M.; Wu, J.-L., MS-FINDER Assisted in Understanding the Profile of Flavonoids in Temporal Dimension during the Fermentation of Pu-erh Tea. Journal of Agricultural and Food Chemistry 2022.

3. Chen, S.-S.; Bai, J., Antitumor potential of tricyclic pyridone analogues from an entomopathogenic fungus, Fusarium avenaceum SYKC02-P-1. Journal of Asian Natural Products Research 2022, 1-8.

4. Chen, S.-S.; Huang, G.; Liao, W.; Gong, S.; Xiao, J.; Bai, J.; Wendy Hsiao, W. L.; Li, N.; Wu, J.-L., Discovery of the bioactive peptides secreted by Bifidobacterium using integrated MCX coupled with LC–MS and feature-based molecular networking. Food Chemistry 2021, 347, 129008.

5. Chen, S.-S.; Fu, Y.; Bian, X.; Zhao, M.; Zuo, Y.; Ge, Y.; Xiao, Y.; Xiao, J.; Li, N.; Wu, J.-L., Investigation and dynamic profiling of oligopeptides, free amino acids and derivatives during Pu-erh tea fermentation by ultra-high performance liquid chromatography tandem mass spectrometry. Food Chemistry 2022, 371, 131176.

6. Gong, S.; Zhuo, Y.; Chen, S.-S.; Hu, X.; Fan, X.-X.; Wu, J.-L.; Li, N., Quantification of Osimertinib and Metabolite–Protein Modification Reveals Its High Potency and Long Duration of Effects on Target Organs. Chemical Research in Toxicology 2021, 34 (11), 2309-2318.

7. Qiu, F.; Xi, L.; Chen, S.-S.; Zhao, Y.; Wang, Z.; Zheng, Y., Celastrol Niosome Hydrogel Has Anti-Inflammatory Effect on Skin Keratinocytes and Circulation without Systemic Drug Exposure in Psoriasis Mice. Int J Nanomedicine 2021, 16, 6171-6182.

8. Liao, W.; Khan, I.; Huang, G.; Chen, S.-S.; Liu, L.; Leong, W. K.; Li, X. A.; Wu, J.; Wendy Hsiao, W. L., Bifidobacterium animalis: the missing link for the cancer-preventive effect of Gynostemma pentaphyllum. Gut Microbes 2021, 13 (1), 1847629.

9. Yan, G.; Li, J.; Chen, S.-S.; Liu, Y.; Wu, J.-L.; Zhu, X.-M.; Li, N., New limonoids from the fruits of Melia toosendan and their autophagic activities. Phytochemistry Letters 2020, 35, 15-22.

10. Kang, W.; Li, J.; Li, D.; Li, Z.; Chen, S.-S.; Hua, H.; Bai, J., New benzyl-aporphine alkaloids from Thalictrum cultratum. Natural Product Research 2019, 33 (21), 3176-3179.

11. Wang, Z.; Chen, S.-S.; Sang, X.; Pan, H.; Li, Z.; Hua, H.; Han, A.; Bai, J., Lecanicillolide, an α-pyrone substituted spiciferone from the fungus Lecanicillium sp. PR-M-3. Tetrahedron Letters 2017, 58 (8), 740-743.

12.   Wang, Z.-Y.; Sang, X.-N.; Sun, K.; Huang, S.-D.; Chen, S.-S.; Xue, C.-M.; Ban, L.-F.; Li, Z.-L.; Hua, H.-M.; Pei, Y.-H.; Bai, J., Lecanicillones A–C, three dimeric isomers of spiciferone A with a cyclobutane ring from an entomopathogenic fungus Lecanicillium sp. PR-M-3. RSC Advances 2016, 6 (85), 82348-82351.